chemist - Biotech Resume Search
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chemist Resume

Desired Industry: Biotech SpiderID: 8957
Desired Job Location: Cambridge, Massachusetts Date Posted: 9/27/2006
Type of Position: Full-Time Permanent Availability Date:
Desired Wage:
U.S. Work Authorization: Yes
Job Level: Experienced with over 2 years experience Willing to Travel:
Highest Degree Attained: Doctoral Willing to Relocate: Undecided

A research scientist position to apply my skills in synthetic organic chemistry in the drug discovery and development

ArQule Inc., Woburn, MA 2001V 2006

Senior Investigator I (promoted, 2005), Investigator II (promoted, 2003), Investigator I
X Developed over 40 transformations in more than 150 focused libraries
X Developed novel chemotypes in hit follow-up projects V resulted in 3 series of 2nd lead generation in the research of cardiovascular and metabolic diseases
X Developed pyrimidine and fused thiazole-pyrimidine chemotypes as P38 and PTK inhibitors
X Developed in-situ isonitrile formation in parallel synthesis V improved IP positions in drug designs
X Solved key chemistry problems V successfully salvaged more than 10 projects from failures
X Expedited multi-parameter chemistry optimization via Design of Experiment (DoE) V reduced development time from regular 2 months to 1 week

NeuroLogic Inc., Maryland, MD 1999 V 2001
Staff Scientist
X Designed and developed 2 new chemical entities in the treatment of Alzheimers disease
o Structure-based design and synthesis of protein kinase C activators as -secreatase promoters V resulted in 2 publications and 1 US patent application
o Independently developed new peptidomimetics as -secreatase inhibitors V 1 US/WO patent
X Developed more than 15-step practical approach for active pharmaceutical intermediate (API) scale-up V timely delivered API for amyloid-beta studies on transgenic mice
X Prepared chemistry details for SBIR grant and patent applications
X Successfully set up chemistry lab from ground zero

Georgetown University Medical Center, Washington D.C. 1996 V 1999
Postdoctoral fellow with Professor Alan P. Kozikowski
X Accomplished proof of the concepts V strongly supported renewals of two NCI/NIH grants
X Developed 3 generations of protein kinase C activators on the structure-based designs V published 6 papers and 2 US/WO patents
X Discovered novel phosphatidylinositol 3-kinase inhibitors as anticancer agents V published 5 papers and 1 US patent
o Phospholipid conjugate went through pre-clinic study under NIH/RAID program
X Explored pro-drug type of 1-sphingosine phosphate - improved its solubility for bioassays
o 2 publications
X Completed more than 20-step scale-up of phosphatidyl inositol ether lipids V quickly delivered high quality API for the preclinical study under NIH/RAID program

* Ph.D. Organic chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, ShangHai, China, 1996 (with Prof. Yu-Lin Wu)
* M.S. Organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin, China (with Prof. Zhengmin Li)
* B.S. Organic Chemistry, NanKai University, Tianjin, China

American Chemical Society

X Experienced in the synthesis of diverse organic compounds in solution phase and solid phase chemistry, as well as using Microwave technology
X Hands on experience in novel compounds characterization with LC-MS, 1D/2D NMR, and purification with prep-TLC, flash column chromatography, AnaLogiX , HPLC
X Skillful in the application of chemical based software and drug-like molecules designs
X Quick data interpretation using Pipeline Pilot and Spotfire

Additional Information:
5 US patent, and 18 publications since 1997

Candidate Contact Information: has chosen not to make contact information available on this page.
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