|Desired Industry: Biotech
|Desired Job Location: Thousand Oaks, California
||Date Posted: 2/9/2006
|Type of Position: Full-Time Permanent
||Availability Date: 3/06/06
|Desired Wage: 60000
||U.S. Work Authorization: Yes
|Job Level: Experienced with over 2 years experience
||Willing to Travel: No
|Highest Degree Attained: Bachelors
||Willing to Relocate: Undecided
Dedicated and self-motivated biotechnology researcher with extensive industry and well-published academic experience conducting comprehensive laboratory development and testing of cutting-edge human therapeutics and of biological assay protocols.
* Research and Development: Proven expertise working independently and on cross-functional teams to design, test, and develop new biotechnology products. Adept at managing all stages of laboratory assays, from experimental design through statistical data analysis and reporting. History of success conducting high-result screenings to isolate and test hit-to-lead compounds.
* Laboratory Management: Skillfully manage laboratory operations, inventorying and ordering supplies, reconciling accounts, training and supervising new staff in appropriate procedures and materials handling. Excel at ensuring process compliance with all applicable regulations.
* Communications: Demonstrate outstanding written and oral communication and ability to convey detailed information succinctly to all levels of audience. Strong record of well-received juried publications and conference presentations in the field of cardiac electrophysiology.
* Technical Knowledge: Expert command of ion channel and electrophysiological techniques and methodologies, including patch clamping, ion transient imaging with fluorophotometry and ratiometric dyes, and cell culture development and harvesting. Software proficiencies include Microsoft Office Suite, ORIGIN, MetaFluor Analyst, pCLAMP, DataXpress, and proprietary biotechnology industry applications.
Amgen, Inc., Thousand Oaks, CA, 10/2004 to Present
--Associate Scientist, Neuroscience
Serve as bench scientist in Neuroscience division for leading biotechnology developer of human therapeutics charged with coordination of conventional and medium-throughput electrophysiological techniques and of parallel multiple patch clamping system to screen hit-to-lead compounds. Independently harvest and prepare cell cultures for evaluation within PatchXpress parallel patch clamping system. Monitor and maintain primary cell culture lines hosting stably transfected HE ion channels. Develop optimal collaborations across research departments to support timely and successful performance of pharmaceuticals research.
* Accurately screened 700+ compounds in a single platform, discovering numerous hit-to-lead compounds and subsequently conducting significant dose-response assays.
* Successfully developed and implemented PatchXpress testing protocol targeted to specific ion channel family.
Duke University Medical Center, Durham, NC, 4/2001 to 10/2004
Neonatal-Perinatal Research Institute
--Research Analyst I, Department of Pediatrics, Division of Neonatology
Played key support role in seamless transfer of Heart Development Team from Medical College of Georgia to Duke University. Ordered supplies, tracked invoices, and assisted in reconciliation of monthly expenditure reports for new lab. Continued to perform and publish research in developmental cardiac electrophysiology using conventional single cell patch clamping and intracellular ion transient imaging methods and protocols previously standardized by Heart Development Team.
* Trained 4 new hires in proper handling and maintenance of primary tissue cultures.
* Performed cutting-edge research that directly contributed to grant proposals leading to multimillion-dollar support funding.
Medical College of Georgia, Augusta, GA, 10/1990 to 3/2001
Institute for Molecular Medicine & Genetics
--Research Assistant II/III/IV, Heart Development Group
Consistently advanced through increasing levels of responsibility as strongly contributing member of laboratory research team. Managed lab and trained 6 support staff in precise performance of assays in the field of cardiac electrophysiology, leveraging expert proficiency in intracellular ion transient imaging with fluorophotometry and ratiometric dyes to observe and analyze stages and processes of embryonic heart development as expressed in myocytes derived from animal models. Skillfully employed perforated patch-clamp stimulation of single-cell calcium transients and conducted successful simultaneous field simulations. Managed, analyzed, and presented research data using Microsoft Office, Microsoft FrontPage, pCLAMP, and Microcal Origin.
* Co-authored numerous research articles in the field of developmental cardiac electrophysiology, including a cover article for Journal of Clinical Investigation.
* Recruited as member of Heart Development Group by Duke University, 2001.
Bachelor of Science in Biology
Augusta State University, Augusta, Georgia
Associate of Arts in Journalism
Dalton College, Dalton, Georgia
ADDITIONAL TRAINING AND PROFESSIONAL DEVELOPMENT
Duke University Medical Center IRB, Durham, NC
* “Protecting Research Subjects,” 2003
* “Ethical and Regulatory Considerations when Bringing a Medication to Market,” 2003.
Please see Experience.
PUBLICATIONS AND PRESENTATIONS
1. Chuck, E. T., Burch, J., Creazzo, T. L., “Acute effects of FGF8 on calcium transients in early embryonic chick heart.” In preparation.
2. Hutson, M.R., Zhang, P., Stadt, H. A., Sato, A., Li, Y. X., Burch, J., Creazzo, T. L., and Kirby, M. L., “Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx,” Developmental Biology (in submission).
3. Creazzo, Tony L., Burch, Jarrett, and Godt, Robert E., “Calcium buffering and excitation-contraction coupling in developing avian myocardium,” Biophysical Journal 86: 966-977, 2004.
4. Kitchens, Susan A., Burch, Jarrett, Creazzo, Tony L., “T-type Ca2+ current contribution to Ca2+-induced Ca2+ release in developing myocardium,” Journal of Molecular and Cellular Cardiology 35: 515-523, 2003.
5. Pipkin, W., Johnson, J. A., Creazzo, T. L., Burch, J., Komalavilas, P., and Brophy, C. “Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart,” Circulation 107 (3): 469-476, 2003.
6. Farrell, Michael J., Burch, Jarrett L., Kumiski, Donna, Stadt, Harriet, Godt, Robert E., Creazzo, Tony L., and Kirby, Margaret L. Kirby, “FGF-8 in the ventral pharynx alters development of myocardial calcium transients after neural crest ablation,” Journal of Clinical Investigation 107 (12): 1509-1517, 2001 [Cover article].
7. Farrell, M., Burch, J., Kumiski, D., Stadt, H., Creazzo, T., and Kirby, M., “Pharyngeal endoderm produces a factor that suppresses development of myocardial calcium transients,” Developmental Biology 210 (1): 186, 1999.
8. Waldo, Karen, Zdanowicz, Marzena, Burch, Jarrett, Kumiski, Donna H., Stadt, Harriet A., Godt, Robert E., Creazzo, Tony L., and Kirby, Margaret L. “A novel role for cardiac neural crest in heart development,” Journal of Clinical Investigation 103: 1499-1507, 1999.
9. Creazzo, T. L., Burch, J. L., and Brotto, M. A. P., “Excitation-contraction coupling in cardiac dysmorphogenesis.” In: The Developing Heart, ed. Ostadal, B., Nagano, M., Takeda, N., and Dhalla, N.S. (Philadelphia: Lippincott-Raven Publishers), 1997.
10. Creazzo, T. L., Brotto, M. A. P., and Burch, J., “Excitation-contraction coupling in the day 15 embryonic chick heart with persistent truncus arteriosus,” Pediatric Research 42: 731-737, 1997.
11. Chu, T. C., Burch, J. L., Brotto, M. A. P., Creazzo, T. L., Han, J., Han, G. Y., and Potter, D. E., “Elevation of intracellular Ca++ concentration in rabbit nonpigmented ciliary epithelial cells by allicin,” Comparative Biochemistry and Physiology 115C: 89-94, 1996.
12. Creazzo, T.L., and Burch, J., “Berger, R. P., “Reduced Ca++ transients and Ca++ currents during early and late cardiac dysmorphogenesis.” FASEB Journal, 1995.
13. Creazzo, T. L., Burch, J., Redmond, S., and Kumiski, D., “Myocardial enlargement in defective heart development,” Anatomical Record, 239: 170-176, 1994.
1. Burch, J., Hutson, M., Stadt, H., Creazzo, T. L., and Kirby, M., “Reducing FGF8 signaling rescues the early functional and morphological cardiac anomalies in cardiac neural crest-ablated chick embryos,” American Society of Cell Biology, Washington DC, December 2004.
2. Burch, J., Ing, R., Hutson, M., Creazzo, T. L., and Kirby, M., “Morphological & myocardial functional defects after vitelline vessel clipping in the chick embryo,” Weinstein Cardiovascular Development, Cambridge, MA, May 2003.
3. Burch, J., and Creazzo, T. L., “Calcium current development in the embryonic chick heart,” Biophysical Society, New Orleans, March 1994.
4. Burch, J., and Creazzo, T. L., “T-type calcium current declines with development in the embryonic chick ventricle,” International Union of Physiological Sciences, Glasgow, Scotland, August 1993.
Application for United States Patent, United States Patent and Trademark Office
Docket No. 9138-0079US
Inventors: Colleen Brophy, Jarrett Burch, Tony L., Creazzo, John A. Johnson, Padmini Komalavilas, Walter J. Pipkin
Title: “Methods for increasing the rate of heart muscle contraction”
Available upon request.
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