Chemistry Educator Staff Scientist - Biotech Resume Search
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Chemistry Educator/Staff Scientist Resume


Desired Industry: Biotech SpiderID: 43233
Desired Job Location: Dallas, Texas Date Posted: 9/16/2010
Type of Position: Full-Time Permanent Availability Date: 9/20/2010
Desired Wage: 75000
U.S. Work Authorization: Yes
Job Level: Experienced with over 2 years experience Willing to Travel: Yes, 25-50%
Highest Degree Attained: Doctoral Willing to Relocate: Yes


Objective:
A challenging position that allows for increased scientific knowledge and professional development.


Experience:
•Experienced Chemist with 7 years of laboratory and industrial experience, including insight regarding FT-ICR mass spectrometric techniques and pre-clinical drug development for the management of assigned drug metabolism absorption, distribution, metabolism and excretion (ADME) studies.

•Staff scientist/study director responsible for technical client interactions and the technical conduct of ADME studies, as well as for the interpretation, analysis, documentation, and preparing technical reports of results.

•Designed study protocols and directed GLP and non-GLP in vivo ADME studies in laboratory animals following FDA, EPA, CFR and OECD regulations (guidelines), and departmental SOPs.

•Experience in performing metabolite profiling of radiolabeled drugs by HPLC to elucidate biotransformation pathways and conducted structure elucidation studies using mass spectral and NMR data to identify biotransformation products in both pre-clinical ADME and human AME studies.

Recent Employment History
Covance Laboratories, Study Director, CRO Division, Madison, WI; 2008 – February 2010
•Directed several pre-clinical studies of drug metabolism including absorption, distribution, metabolism, and excretion (ADME). These studies involved the assessments of radiolabeled compounds to determine the biodistribution and metabolic fate of drug-related materials. Provided the appropriate supervision, monitoring, interpretation, analysis and technical report preparation for assigned drug metabolism studies.

•Managed various aspects of radiolabeled drug studies in laboratory animals. These studies involved mass balance, routes of excretion and with additional analyses, such as quantitative whole body autoradiography (QWBA) assessments. Knowledgeable of the various study aspects for the conduct of ADME studies and analyses.

•Used metabolite profiling, mass spectral and NMR data of radiolabeled drugs to elucidate biotransformation pathways and to identify biotransformation products.

•Experience with analytical HPLC method development to optimize the separation of radiolabeled metabolites in biological matrices.

•Provided periodic study updates to appropriate clients and study teams. Updates included technical and timing/cost issues for assigned drug studies. Able to organize, maintain and manage various projects and client communications.

•Discussed study problems or scope changes with the client. Suggested solutions and took action to solve study problems by identifying the resources to address study concerns. Demonstrated resourcefulness in order to achieve results.

•Participated in a departmental improvement project as a study direction representative. Provided input for cost-saving measures regarding radioactivity disposal. Demonstrated ability to work with various members from different teams to improve overall work efficiency.
Graduate Research Experience
Purdue University; West Lafayette, IN; Spring 2002 – 2007
•Synthesized three quinoline precursors to generate distonic radical ions using a multi-step gas-phase synthesis in a dual-cell Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Demonstrated that variation of charge and radical sites cause changes in biradical’s reaction efficiencies with various compounds. Acquired new laboratory skills by being mentored by organic synthetic chemists outside the group.

•Employed the distonic ion approach to examine the intrinsic chemical properties of o-benzynes toward organic substrates and nucleic acid components in a dual-cell FT-ICR. Proved that these ions prefer to maintain the strong orbital overlap of their nominally nonbonding orbitals. The results suggest that o-benzyne intermediates can be used to destroy malignant tumor cells via addition/elimination pathways. Acquired data that is reinforced by gas-phase reactivity studies of o-benzynes gathered by other colleagues.

•Utilized ab initio (Hartree Fock) molecular orbital calculations to explain the reactivity trends of the 3,4-, 5,6- and 7,8-didehydroisoquinolinum ions. Confirmed that the charge site of the o-benzyne isomers effect their reaction rates. The results support computational studies that the electron affinity of arynes correlates with the through-space distance between the charge site and closest radical site. Linked theory with factual results obtained by mass spectrometry for various o-benzynes studied.

•Synthesized various air-sensitive novel boranes and used them to develop selective gas-phase ion-molecule reactions to identify functionalities in protonated poly- and monofunctional oxygen- and nitrogen-containing analytes in a collaborative project with Eli Lilly. Proved that (N,N-diethylamino)dimethylborane can be used to elucidate the amido functionality in protonated monofunctional nitrogen-containing analytes. The utility of this method will aid in the development of rapid high through-put screening techniques for complex mixtures. Demonstrated ability to work on a multidisciplinary team.

•Calculated solvation energies of ion-molecule complexes using ab initio (Hartree Fock, density functional theory) molecular orbital calculations to explain the selectivity of synthesized (N,N-diethylamino)dimethylborane for the amido functionality. Provided support for the specificity of the aminoborane for the amido functionality in the presence of other nitrogen-containing analytes. Diligent work ethic translated study into a cover feature article in the Journal of Organic Chemistry.

•Designed, implemented and maintained a chemical inventory system in the laboratories. Developed a chemical inventory for approximately 1700 chemicals using Microsoft Excel. Maintained the data base by cataloguing the chemicals’ CAS numbers, location, vendor information, etc. Worked well in a team environment to help others within the group.
•Managed the general order of the laboratory. Responsible for laboratory supplies and equipment maintenance.

Graduate Teaching Assistant
Purdue University; West Lafayette, IN; 2001 – 2005
•Taught general and organic chemistry laboratory sections to undergraduates and gave pre-laboratory lectures.

•Supervised laboratory experiments and conducted recitations.

•Administered and graded lab reports, quizzes and exams.






Education:
Education
Doctor of Philosophy in Chemistry; (Bio-Organic) Purdue University; West Lafayette, IN; (2007) Dissertation: “The Development of an Ion-Molecule Reaction-Based Mass Spectrometric Method for the Identification of Protonated Monofunctional Nitrogen-Containing Compounds and A Study on the Effects of Heteroatoms on the Chemical Reactivity of o-Benzyne Derivatives by Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS)”
Thesis Advisor: Professor Hilkka I. Kenttämaa

Bachelor of Arts (Chemistry, Cum Laude) Franklin College; Franklin, IN (2001)


Affiliations:
Professional Memberships and Affiliations
•American Society for Mass Spectrometry
oServed as Oral Session Chair for the “Fundamentals and Applications of Ion Activation: Alternatives to CID” during the 56th Annual Meeting of the American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. Denver, Colorado; June 2008.

•National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE)
oServed as the College Planning Committee Co-chair for the 2008 Midwest NOBCChE Regional Biotechnology Conference. Indianapolis, Indiana; October 2008
oServed as the College Technical Speaker Planning Committee Chair for the 2009 Biotechnology NOBCChE Conference. Indianapolis, Indiana; October 2009
oStudent member (2002 – 2007)
oServed as Vice President for the Purdue University Chapter (2004)



Skills:
Microsoft suite of programs


Additional Information:


Manuscripts
Campbell, K.M.; Watkins M.A.; Li, S.; Fiddler, M.; Winger, B.E. and Kenttämaa, H.I., Functional-Group Selective Ion-Molecule Reactions: Mass Spectrometric Identification of the Amido Functionality in Protonated Monofunctional Compounds. J. Org. Chem.; 2007; 72(9) pp 3159 – 3165

Jackson, A.U.; Werner, S.R.; Talaty, N.; Song, Y.; Campbell, K.M.; Cooks, R.G.; Morgan, J.A.; Targeted Metabolomic Analysis of Escherichia coli by Desorption Electrospray Ionization (DESI) and Extractive Electrospray Ionization (EESI) Mass Spectrometry. Anal. Biochem.; 2008; 2(375) pp 272 – 281

Campbell, K.M.; Li, S.; Winger, B.E. and Kenttämaa, H.I., Selective Ion-Molecule Reactions: Mass Spectrometric Identification of the Amino Functionality in Protonated Pre-derivatized Compounds. in preparation




Campbell, K.M.; Amegayibor, F.S.; Nash, J.J. and Kenttämaa, H.I., Comparison of the Chemical Properties of o-Benzynes to Other Biradicals by Using the Distonic Ion Approach and FT-ICR. in preparation

Amegayibor, F.S.; Nizzi, K.; Campbell, K.M.; Yurkovich, M.; Petucci, C.J.; Nash, J.J. and Kenttämaa, H.I., Gas-phase Reactivity Studies of Positively Charged Isomeric Didehydroarenes. in preparation

Presentations
Karinna M. Campbell; Michael A. Watkins; Sen Li; Marc Fiddler; Brian Winger; Hilkka I. Kenttämaa, Functional-Group Selective Ion-Molecule Reactions: Mass Spectrometric Identification of the Amido Functionality in Protonated Monofunctional Compounds. Oral Presentation at the 231st American Chemical Society National Conference. Atlanta, Georgia; March 2006.

Karinna M. Campbell; John J. Nash; Hilkka I. Kenttämaa, A Comparative Reactivity Study of o-Benzynes and Other Biradicals Toward Nucleic Acid Components by Using the Distonic Ion Approach and FT-ICR Mass Spectrometry. Poster Presentation at the 53rd Annual Meeting of the American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. San Antonio, Texas; June 2005.

Karinna M. Campbell; John J. Nash; Hilkka I. Kenttämaa, A Comparative Reactivity Study of o-Benzynes and Other Biradicals Toward Nucleic Acid Components by Using the Distonic Ion Approach and FT-ICR Mass Spectrometry. Oral Presentation at the 32nd Annual Meeting of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers. Orlando, Florida; March 2005.

Karinna M. Campbell; Michael A. Watkins; Brian Winger; Hilkka I. Kenttämaa, Ion-Molecule Reactions for Functional Group Characterization in Protonated Monofunctional Nitrogen-Containing Compounds. Poster Presentation at the 30th Biannual Meeting of the Reaction Mechanism Conference. Evanston, Illinois; June 2004.

Karinna M. Campbell; Michael A. Watkins; Brian Winger; Hilkka I. Kenttämaa, Ion-Molecule Reactions for Functional Group Characterization in Protonated Monofunctional Nitrogen-Containing Compounds. Poster Presentation at the 52nd Annual Meeting of the American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. Nashville, Tennessee; May 2004.

Karinna M. Campbell; F. Sedinam Amegayibor; John J. Nash; Hilkka I. Kenttämaa, Comparison of the Chemical Properties of o-Benzynes to Other Biradicals by Using the Distonic Ion Approach. Poster Presentation at the 51st Annual Meeting of the American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics. Montreal, Canada; May 2003.


Reference:
Available upon request.


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