PHYSIOLOGICAL SCIENTIST - Healthcare Resume Search
PHYSIOLOGICAL SCIENTIST - Healthcare Resume Search
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PHYSIOLOGICAL SCIENTIST Resume


Desired Industry: Healthcare SpiderID: 79484
Desired Job Location: Rochester, New York Date Posted: 6/27/2017
Type of Position: Full-Time Permanent Availability Date: 06/28/17
Desired Wage:
U.S. Work Authorization: Yes
Job Level: Experienced with over 2 years experience Willing to Travel: Yes, Less Than 25%
Highest Degree Attained: Doctoral Willing to Relocate: Yes


Objective:
Detail-oriented, astute, and results-driven scientist with professional experience, encompassing automated assay systems, assay development, laboratory management, molecular biology, clinical research, PK/PD analysis, and validation. Armed with proven expertise in communication, problem-solving, team leadership, didactic instruction and process streamlining.


Experience:
RESEARCH EXPERIENCE

University of Rochester, Rochester, NY (2005–Present)

POST-DOCTORAL FELLOWSHIP – Experimental Therapeutics Department 2016–Present
- Led the creation and validation of a progressive disease model using established and novel biomarkers to identify patient subgroups enabling efficient clinical trial design and more accurate disease prognosis.
- Provide pharmacokinetic and pharmacodynamics analysis (compartmental and non-compartmental) prior to phase II trials, contributing to effective dose selection.
- Collaborated across multidisciplinary teams consisting of scientists and clinicians to inform experimental design by blending basic science data and clinical research data.

HIGHLIGHTS:
- Strategically directed data management analysis in alignment with standard operating procedure requirements.
- Supervise and contribute to multi-cohort analysis teams comprised of programmers and biostatisticians tasked to develop systematic analytical tools designed to identify therapeutic effects in big data sets following thousands of patients.
- Directed and performed assay development to improve or adapt based on the needs of the project.
- Developed clinical trial modeling tools for progressive diseases alongside IBM’s Watson machine learning software to review and incorporate unstructured patient data.

PH.D. CANDIDATE – Cellular and Molecular Pharmacology and Physiology Department 2012–2016
- Performed analytical testing utilizing molecular tools, improvised technical devices, and pharmacological interactions to determine mechanistic interactions on the molecular and cellular level.
- Designed and implemented a small molecule assay for the discovery of specific calcium channel blockers.
- Conducted the isolation and preparation of primary cell lines for pharmacological studies.
- Wrote analytical and technical documents for presentation at conferences or publication of results and methodologies in scientific journals.

HIGHLIGHTS:
- Identified and characterized a unique signaling pathway involved in the pathogenesis of multiple diseases and established potential targets for pharmacological therapeutic intervention.
- Implemented a small molecule screen protocol used to successfully identify calcium channel inhibitors by utilizing skills in scientific assay design for the discovery and validation of inhibitor specificity.
- Developed formulations of inhibitory cocktails for animal and cellular studies leading to protocol optimization and permitting the mechanistic evaluation of physiological signal strength and origin.
RESEARCH TECHNICIAN – Dermatology Department 2006–2009
- Studied human melanocyte biology with a focus on signaling pathways in melanoma and tumorigenesis.
- Performed tasks in Biosafety Level II (BSL2) environments, cultivating fibroblasts and melanocytes isolated from human tissues, and providing physiological accuracy and scientific relevance to the research.
- Established and documented analytical techniques to communicate raw and processed data to my superiors.
- Maintained working relationships with local clinics that provided human tissue samples.

HIGHLIGHTS:
- Earned recognition as laboratory manager, responsible for general upkeep and smooth operations of the laboratory by drafting protocols, training laboratory personnel in equipment use, performing calibrations, troubleshooting, and maintaining equipment and supplies.
- Spearheaded laboratory technique development unique to each assignment.
- Successfully identified several signaling mechanisms unique to cancerous tissues, ultimately leading to numerous publications.

CLINICAL LABORATORY TECHNICIAN (INTERN) – Neurology Department Summer 2005
- Performed immunohistochemical staining on biopsied human nerve and muscle tissue for physician diagnosis.
- Analyzed tissue sections for muscle fiber densities as an indication of muscular dystrophy



TEACHING-RELATED EXPERIENCE

University of Rochester, Rochester, NY (2007–Present)
RESEARCH SUPERVISOR AND MENTOR 2007–Present
- Apprentice four medical students and five graduate students.
- Provide assistance on the research project development in the laboratory and office; explaining scientific theory; as well as guiding students through basic and complex laboratory and analytical methods.
- Formulate and guide the scientific thought process and analysis of medical, scientific, and clinical data.

PHARMACOLOGY CLASS LEAD 2013–2016
- Taught pharmacodynamics and pharmacokinetics through patient case studies.
- Reinforced of core concepts of drug dosing and metabolism in human physiology.
- Attained increased comprehension of physiological drug action through case studies.

CELLULAR AND MOLECULAR PHYSIOLOGY TEACHING ASSISTANT 2013–2015
- Thoroughly assessed molecular mechanisms within the neuromuscular physiological processes.
- Aid 1st & 2nd year graduate students via peer advising/mentoring, office hours, grading, and giving lecture reviews


Education:
Doctor of Philosophy in Cellular and Molecular Pharmacology and Physiology Aug 2016
Hodge Award
University of Rochester, Rochester, NY

Master of Science in Pharmacology May 2012
University of Rochester, Rochester, NY

Bachelor of Science in Biology May 2006
Clarkson University, Potsdam, NY


Skills:
Live-cell Microscopy Techniques: Phase-contrast | Epi-fluorescent | Confocal | Multi-photon | TIRF| Patch-clump Chemical, Electrical, and Optical ‘photo-uncaging’ Tissue/Cell Stimulation Fluorescent Calcium Indicators | Fluorescent pH Indicators | Cellular Injection
Genomic and Proteomic Analysis: Single-cell PCR | rtPCR, | qPCR | siRNA Silencing | Western Blot| ELISA Immunocytochemistry and Immunohistochemistry
Programmable Assay Systems: Small-molecule screening | Automated Multi-Readout Fluidic Instrumentation Automated Plate-Based Assay Systems
Live Tissue & Cell Culture: Primary Cell Isolation & Purification| FACS | Flow Cytometry | Transfection Transduction | Transformation | Animal Handling| Disease Modeling
Software: Microsoft Office Applications (Access, Word, Excel, PowerPoint, Outlook) | R GIMP | Corel Draw Pro | Photoshop | Illustrator | MATLAB | AutoCAD TillVision | Origin | Windows | iOS | Linux | BIOS | Android | C++
Languages: English (native), German (intermediate)


Additional Information:
PROFESSIONAL AFFILIATIONS

Member, Clinical Trials Working Group 2016–Present
Member, Upstate New York Pharmacology Society 2011–Present


ACTIVITIES

Member, Porsche Club of America (High-Performance Driver’s Ed) 2012–Present
Member, Upstate New York Homebrewers Association (UNYHA) 2007–Present
Communications Chair, Graduate Student Society 2014–2016
Acting Member, Signal Transduction 2011–2016
Member, Planning Committee, Clarkson Union Board 2003–2006


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