|Desired Industry: Biotech
|Desired Job Location: San Diego, California
||Date Posted: 3/27/2016
|Type of Position: Full-Time Permanent
||Availability Date: Immediately
||U.S. Work Authorization: Yes
|Job Level: New Grad/Entry Level
||Willing to Travel: Yes, Less Than 25%
|Highest Degree Attained: Doctoral
||Willing to Relocate: Yes
A dedicated and highly motivated Scientist offering success in related fields of research and development. Team player with solid written and oral communication skills anchored by publications and conference presentations. Exceptional problem solving, communication, and multi-tasking skills. Seeking a challenging, productive, and dynamic work environment to make significant contributions towards next generation translational research.
Dept. of Bioengineering, Ghosh Research Group, UC Riverside 03/2016-Present
Postdoctoral Research Fellow
-Independently design, execute, and interpret results from experiments to further enhance
therapeutic potential (benefit/risk profile) of site-targeting drug delivery system while supervising
undergraduate and graduate students
-Demonstrate excellent organizational, record keeping, oral and written communication skills
Dept. of Bioengineering, Ghosh Research Group, UC Riverside 09/2011-03/2016
Graduate Student Researcher
-Evaluated therapeutic efficacy of drugs for suppression of chronic vascular inflammation and regression associated with cardiovascular and diabetic conditions
-Formulated, characterized, and optimized drug-encapsulated lipid/polymeric nanoparticles to enhance drug efficacy by 70-fold
-Developed and leveraged quantitative and qualitative cell-based methodologies to understand cell fate and function
Research Group for Computational and Systems Biology, UIUC 06/2009-2011
Undergraduate Research Intern
-Assisted in the metabolomics profiling of butanol-producing anaerobe Clostridium beijerinckii for increased biofuel production by batch fermentation and optimized protocols
University of California, Riverside 03/2016
Ph.D. Bioengineering. GPA: 3.73
Thesis: Site-targeting Nanotherapeutic for Suppression of Vascular Inflammation
University of Illinois at Urbana-Champaign 05/2011
B.S. Chemical and Biomolecular Engineering. GPA: 3.11
Leadership Roles: Proven leadership & supervisory abilities, developed through mentoring undergraduate and graduate students in successful pursuit of research goals and daily life. Established protocols and SOPs for entire laboratory use. Served as teaching assistant for multiple senior level engineering courses and evaluated student’s abilities to solve problems and develop presentation skills to effectively communicate to their peers. Established interdisciplinary collaborations across various academic institutions and industry to further strengthen research findings resulting in notable proof-of-concept in vitro, ex vivo, and in vivo studies.
Cell Culture: 5+ years of mammalian cell culture experience (human/mouse endothelial cells, Monocytes & Macrophages, Primary and Cell line culture and maintenance). Cell passaging/expansion, Cell freezing/thawing, Cell Decellularization, Immunological Assays, Primary Cell magnetic bead Isolation from whole blood.
Cell & Molecular Biology: Live cell and Time-lapse imaging, Phase contrast/Confocal/Fluorescence Microscopy, Scanning Electron Microscopy (SEM), Multichannel pipetting, Immunohistochemistry, Flow Cytometry, Western Blot, SDS-PAGE, Gel electrophoresis, ELISA, mitochondrial superoxide, calcium and nitric oxide fluorescence imaging, E.coli transfection of plasmids.
Animal Handling & Procedures: Small animal handling, Tissue/Organ Harvesting and Cryosectioning, Organ bath Isometric Tension Measurements, Mouse Retinal capillary isolation, Mouse Injections (Intravenous/Intravitreal).
Analytical Techniques: Dynamic Light Scattering (DLS), Electrospray Mass Spectrometry (ESI-MS), UV/Vis Spectroscopy.
Engineering: Drug Delivery Analysis, Nanotechnology, Nanoparticles (liposomes, PLGA-PEG particles), Therapeutics,
Non-immunogenic Antibody Fragmentation.
Computer Software: Microsoft Office, NIS Elements, Image J, Graphpad Prism, Origin, FlowJo, Data Analysis.
1. Ardekani S, Scott HA, Gupta S, Eum S, Xiao Y, Brunelle AR, Wilson SM, Mohideen U, Ghosh K. Nanoliposomal Nitroglycerin Exerts Potent Anti-inflammatory Effects.
Scientific Reports. 2015;55:3140-3147
2. Yang X, Scott HA, Monickaraj F, Xu J, Ardekani S, Nitta CF, Cabrera A, McGuire PG, Mohideen U, Das A, Ghosh K. Basement Membrane Stiffening Promotes Retinal Endothelial Activation Associated with Diabetes.
FASEB J. 2015;55:3140-3147
3. Xiao Y, Scott HA, Ardekani S, Williams M, Talbot P, Ghosh K. Aberrant Cell and Basement Membrane Architecture Contribute to Sidestream Smoke-Induced Choroidal Endothelial Dysfunction.
Invest Ophthalmol Vis Sci. 2014;55:3140-3147
4. Milne CB, Eddy JA, Raju R, Ardekani S, Kim PJ, Senger RS, Jin YS, Blaschek HP, Price ND. Metabolic network reconstruction and genome-scale model of butanol-producing strain Clostridium beijerinckii NCIMB 8052.
BMC Systems Biology 2011;5:130.1752-0509-5-130
“Nanoliposomal Nitroglycerin Preparations, Methods of Making and Use Thereof”
Ghosh K, Ardekani S, Gupta S, Mohideen U. Provisional Patent Application#: 62/188,474
HONORS & AWARDS
Graduate Research Mentorship Program (GRMP), UC-Riverside 09/2015
Graduate Student Association Conference Travel Grant, UC-Riverside 01/2013, 11/2015
Dean’s Distinguished Fellowship Award, Bioengineering Graduate Program, UC-Riverside 09/2011-2012
American Heart Association (AHA) 09/2015-Present American Association for the Advancement of Science (AAAS) 05/2013-2014
North American Vascular Biology Organization (NAVBO) 03/2013-2014
Biomedical Engineering Society (BMES)
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